Research brief · Longevity
BPC-157: What 30 Years of Preclinical Evidence Actually Shows
A close reading of the mechanisms, the animal evidence, and the human-data gap.
Research archive · Issue by issue
Every claim leaves a trail.
Research briefs, quick reviews, and methodology notes—organized chronologically and labeled by evidence type.
Research brief · Longevity
Quick brief · Nutrition
What the COSMOS Multivitamin Trial Actually Said
A forthcoming review of the reported cognitive signal and the claims that followed.
Research note · Glycemic control
Bergamot vs Metformin: What the Evidence Actually Shows
Three mechanisms (AMPK, GLP-1R, GLUT-4), 110 patients, zero head-to-head trials. Bergamot's multi-pathway activity is genuinely interesting — but the gap between mechanism and efficacy is wide.
Methodology note · Practice
How we review evidence
Our editorial standards, search methodology, evidence-grading rubric, and conflicts-of-interest policy.
COSMOS · Multivitamin trial
COSMOS Trial Analysis
A detailed breakdown of the COSMOS multivitamin trial — what it tested, what it found, and whether the conclusions match the data.